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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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[DYNAMICS OF CYTOKINE CONCENTRATION IN THE BLOOD OF RATS WITH VARIOUS BEHAVIORAL CHARACTERISTICS AFTER ACUTE EMOTIONAL STRESS]статья
- Авторы: Pertsov S.S., Kalinichenko L.S., Koplik E.V., Alekseeva I.V., Kirbaeva N.V., Sharanova N.E., Vasil'ev A.V.
- Журнал: Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk
- Том: 101
- Номер: 9
- Год издания: 2015
- Первая страница: 1032
- Последняя страница: 1041
- Аннотация: This work was designed to study a change in cytokine content in the peripheral blood of behaviorally passive and active Wistar rats at various time intervals after acute stress on the model of night-time immobilization. A decrease in the concentration of most pro- and anti-inflammatory cytokines in passive animals was most pronounced immediately and, particularly, 3 days after stress exposure. Variations in the blood cytokine profile after experimental stress were lower in behaviorally active specimens. A statistically significant decrease was observed only in the amount of a proinflammatory cytokine IL-1α and anti-inflammatory cytokines IL-4 and IL-13. As differentiated from passive rats, these changes in active specimens were most pronounced 1 day after negative emotiogenic exposure. Our results illustrate a specific involvement of immunoactive substances in the systemic regulation of physiological functions and development of individual resistance to the negative consequences of stress.
- Добавил в систему: Шаранова Наталья Эдуардовна