Stabilization of Enzymes-Antioxidants by Complex and Conjugate Formation with Block Copolymers: Prospects for CNS Treatmentстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
Авторы:
Uglanova S.V.a ,
Popov M.V.b ,
Kurova V.S.a ,
Batrakova E.V.c ,
Manickam D.c. ,
Kabanov A.V.c ,
Klyachko N.L.b
Журнал:
Moscow University Chemistry Bulletin
Том:
65
Номер:
3
Год издания:
2010
Издательство:
Allerton Press Inc.
Местоположение издательства:
United States
Первая страница:
190
Последняя страница:
196
DOI:
10.3103/S0027131410030168
Аннотация:
Nanosized particles with a radius of 16 В± 2 nm based on complexes and conjugates of highly active superoxide dismutase and catalase with polyelectrolyte block copolymer poly(ethyleneimine)-poly(ethylene glycol) and similar bienzyme systems were obtained. Mass spectrometry was used to confirm the crosslinking of enzyme and block copolymer molecules in the nanoparticles that were formed. A significant increase of SOD and catalase stability (up to four times) towards proteolytic degradation under chymotrypsin and trypsin action for 3 h at 37В°C was revealed when enzyme-containing nanoparticles were used for experiments. Antioxidant enzymes-containing polyelectrolyte nanoparticles seem to be promising for BBB penetration and CNS drug delivery. В© 2010 Allerton Press, Inc.
Добавил в систему:
Клячко Наталья Львовна