Аннотация:Results of numerical simulation of (SCI) interaction between strong (SW) shock wave gen-erated after supernova explosion and molecular cloud (MC) have been presented in three-dimension gas-dynamical arrangement. Mach number of hypersonic SW is accepted by seven. Statement of problem: the compressed supernova remnants gas with plane frontal shock wave with hypersonic velocity runs into spherical cloud and interacts with more dense gas of the cloud. Developed computational code is based on numerical solution of the Euler equations for compressible flow. Gas flow equations were represented conservatively for velocities components and energy. The parallel in-house code using OpenMP for PC hybrid system was developed for modeling. The Intel Vtune Amplifier XE was used to profile the code using GPU. More than a quarter of billion cells mesh (1024x512x512) with effective resolution for cloud radius in 124 nodes was implemented. Peculiarities of molecular cloud forming and density fragmentation in time were analyzed during time-consuming simulation. Shock wave strikes the cloud, triggering weak reflected shock waves and transmitted shock that advances in to the cloud. Inner-cloud SW compresses and defragment MC media. Post-processing used allow to find out the circumstances of vortex transfer in MC, ablation and erosion phenomena.