ИСТИНА

Currently, the magnetite nanoparticles (Fe3O4) have been widely used in biomedical research, for example, to increase the image contrast in MRI, immunoassay, etc. In the scientific literature, the magnetic nanoparticles are proposed to use for the treatment of cancer by hyperthermia, to fight tumors by heating previously delivered to them magnetic nanoparticles in the radio frequency magnetic field. There is another possible method of treatment to target delivery and to release a drug near the tumor. Moreover, the magnetic nanoparticles can influence on the chemical reactions in the body, for example, when an enzyme is immobilized on the nanoparticles. Field exposure could lead to the reorientation magnetic particles. Upon the enzyme will be deformed, that it contributes to its activity. Magnetic nanoparticles, coated gold shell, are low toxicity to the body, less aggregate and can be functionalized by organic ligands with sulfa-groups. This paper presents a synthesis of magnetic (Fe3O4) and magnetic gold particles (Fe3O4@Au) with the core-shell structure, confirmed by micrographs HRTEM. For the surface functionalization of nanoparticles lipoic acid was used. Magnetic nanoparticles Fe3O4@Au were stabilized and characterized at different concentrations. In future we are planning to check the possibility of immobilization enzymes on magnetic and magnetic-gold nanoparticles, then to obtain oligomers (particle-particle-enzyme). For functionalization nanoparticles with the gold shell we will use various ligands, including dimerkaptosuccinic acid. To find the most efficient linker between the particle and the protein would be very interesting problem.