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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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The appearance of microorganisms resistance to beta-lactam antibiotics is a threat to the use of these drugs in clinical practice. The most common limitation is the expression of the bacterial enzymes - beta-lactamases. The aim of this study is to find a new betalactamase inhibitors, based on computer modeling, synthesis and biological testing of the compounds obtained.