ИСТИНА

Diabetes mellitus (DM) affects approximately 387 million personsworldwide and is expected to dramatically rise in both industrially developed and developing countries in the next decades (www.idf.org/diabetesatlas, 2014).Diabetic patients have higher susceptibility than nondiabetic individuals to develop major cardiovascular events, such as myocardial infarction, stroke, and CV death, because of an inability of the vascular systems to adequately perfuse tissues and organs relative to their metabolic demand(Levitan, et al. 2004).Diabetes mellitus, whether insulin dependent or not, is associated with increased prevalence of macro- and microangiopathy (Bolinger and Fagrel, 1991). This study was aimed to define the extent of digital capillaroscopy possibilities for the quantification and estimation of the level of microvascular abnormalities in diabetes mellitus. Participants and method. A total of 196 adult persons were examined in the study. The first group consisted of 52 patients with compensated DM,thelevel of glycated hemoglobin (HbA1c) was6.3 ± 0.5 %. The second group included 68 patients without compensation of DM (HbA1c 9.4 ± 1.7 %). The group of volunteers (n=76) included healthy adults with normal blood glucose and without signs of cardiovascular pathology. The capillary circulation in all participants of the study group was examined with the nail-bed using the digital optical capillaroscope developed by the company "AET", Russia. This instrumentis equipped with a sophisticated image-processing program allowing for quantifying the diameters of the arterial and venous segments of the capillaries and their ratio (coefficient of remodeling), perivascular zone size, capillary blood velocity, the degree of arterial loops narrowing and the density of the capillary network. Also we estimated the relative amount of coil-shaped capillaries. Results. The study revealed significant difference in the capillary density and the coefficient of remodeling in comparison of non-diabetic individuals with DMpatients of both groups (p<0, 0008). Significant changes were found for the capillary rarefaction, perivascular zone size in both groups of patients.Furthermore, the number of coil-shaped capillariesdiffered greatly in healthy subjects as comparedto the DM patients. The study did not revealany statistically significant differencesin the capillary density between the patients withcompensated and decompensated DM. Conclusion. Thus, the digital optical capillaroscopyequipped with the state-of-the-art image-processingalgorithm opens up new possibilities for obtaining clinically importantinformation on microvascular abnormalities in patients suffering fromdiabetes mellitus.